The Cleveland Guardians and Houston Astros are set to continue their three-game series on Wednesday night. It was Houston that came away with a 10-9 win in the series opener, and they will now be looking to win the series. Here is a look at some Guardians vs Astros picks and parlays that can be made on Wednesday night.
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Game Details and Betting Picks
Cleveland Guardians vs. Houston Astros Information
Cleveland Guardians vs. Houston Astros
Location of the game: Minute Maid Park, Houston, Texas
Date & Time: Wednesday, May 1, 8:10 PM ET
Where to Watch: MLB Network
Guardians vs. Astros Picks

- Houston Astros -170
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This is a matchup of two of the better teams in the American League, and it should lead to a great matchup on the diamond. Can Top Teams Deliver Another Close Game? Get our top Scores and odds of the day to keep track!
Cleveland Guardians vs. Houston Astros Odds
There will be a ton of odds to check out when putting together Guardians vs Astros picks and parlays, but keeping things simple is a great way to start. This will be an interesting game on the MLB schedule today, and it’s one where the Astros are moneyline favorites at -170.
Looking at the over/under is also important when putting together MLB picks and parlays, and that betting line is set at 8.5 total runs.
Cleveland Guardians vs. Houston Astros Picks & Parlays
Here is a look at four of the bets that you will want to include in your Guardians vs Astros picks and parlays.
Cleveland Guardians vs. Houston Astros Pick:
- Houston Astros -170
Cleveland Guardians vs. Houston Astros Parlay:
- Houston Astros -170
- Over 8.5 Runs
- Jose Ramirez Over 1.5 Hits/Runs/RBIs
- Jose Altuve 2+ Total Bases
When looking to make Astros vs Guardians picks and parlays on Wednesday night, it’s best to find the top option first. The best bet to make in this game is taking the Astros at -170 on the moneyline.
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Cleveland Guardians vs. Houston Astros Betting Analysis
The Cleveland Guardians can make a case for being the best team in the MLB so far this season, but it will be interesting to see if that lasts. Cleveland’s record stands at 19-10 through the first 29 games, despite their low expectations.
Most MLB games today are decided by pitching in 2024, and the Guardians have a team ERA that is sitting at 3.41 on the year. Cleveland is hitting just .248 as a team, and that is an area that will need to improve.
It has not been easy coming up with an Houston Astros betting strategy this season as they are sitting at just 10-19 on the year. Houston does have a team batting average of .265 on the year, but they just haven’t been able to come up with clutch hits.
Pitching has been a big area of weakness for the Astros as they are pitching to a team ERA of 5.01. That is something that will need to improve if this team is going to turn things around.
Houston Astros vs. Cleveland Guardians Betting Picks
There are a number of MLB best bets that should stand out right away when breaking down this matchup on Wednesday night. Even though the Guardians have been the better team all season long, that’s not going to matter in this game.
Betting on the Astros moneyline at -170 is going to be one of the best bets to make as they are going to win for the second straight time in this series. This will also be a game in which both teams score some points, and taking the over 8.5 is another great option.
Jose Ramirez will need to have a big game for the Guardians to keep things close, and he is going to record at least 2 hits, runs or RBIs in this matchup. Finally, betting on Jose Altuve to deliver at the plate is a good option as that is something that he has done all season long.
Discover the latest stats and trends of this matchup here:
May 01 2024 Cleveland Guardians vs Houston Astros Match Recap
The Cleveland Guardians picked up a 3-2 win in extra innings over the Houston Astros in Game 2 of this series. This was the second straight game that went into extra innings as it was another tight battle on the diamond.
Run Line: The Astros were pretty significant favorites on the run line in this matchup at -1.5 (+145). Going with the Guardians and taking the 1.5 runs was the right way to go, but not the best way to back this team.
Money Line: With moneyline odds set at +155 ahead of this game, there was some serious value in backing the Guardians. Cleveland ended up coming up with a big win on the road in extra innings.
Total: With an over/under line set at 8.5 total runs, the oddsmakers were expecting a slug fest in this matchup. That never materialized as not even extra innings could allow this bet to go over that total.
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