National League Central division rivals the St. Louis Cardinals and Milwaukee Brewers meet on Wednesday night in the final game of a two-game series and the last series of the 2022 MLB season between the Cardinals and Brewers.
National League Central Division
St. Louis clinched the National League Central Division pennant with the Cardinals’ 6-2 win over the Brewers on Tuesday night.
National League Wild Card Spot
The St. Louis Cardinals have won the head-to-head season series against the Milwaukee Brewers 10-8. While the Cardinals do not have anything significant to play for, the Brewers need to win and hope for some help to capture the final National League Wild Card spot.
We’ll review the statistics and odds to give you a Cardinals vs Brewers prediction for your betting ticket today.
The first pitch for the Cardinals vs. Brewers is scheduled for 7:40 P.M. ET from American Family Field in Milwaukee, Wisconsin.
Cardinals vs. Brewers Odds
Before making any Cardinals vs. Brewers predictions, we need to review the odds. Online sportsbooks have the moneyline set with the Brewers odds as the betting favorite, listed between -145 and -156.
Cardinals Odds Breakdown
Having already clinched the National League Central division, the St. Louis Cardinals are listed as the underdog on the moneyline between +120 and +137.
Most online sportsbooks have St. Louis (+1.5) as the betting favorite on the run line spread on most sportsbooks, listed between -169 and -179.
Brewers Odds Breakdown
Most online sportsbooks have Milwaukee (-1.5) as the betting underdog on the run line spread, with odds listed between +140 and +150.
Online sportsbooks have the total runs listed at 7. The over is the clear favorite listed with odds between -115 and -120, while the under is listed as the underdog with odds between +100 and +105.
St. Louis Cardinals vs. Milwaukee Brewers Betting Preview
The St. Louis Cardinals enter Wednesday’s game with a 90–65 record (.581 winning percentage). The Cardinals have won the National League Central Division and will finish as the third seed in the National League Playoffs.
2022 MLB Season
St. Louis has seven games remaining in the 2022 MLB season, six of which are against the Pittsburgh Pirates, giving St. Louis flexibility and time to rest any position players to prepare for the post-season.
The St. Louis Cardinals have a 5-5 record in their last ten games, averaging 3.1 runs per game, dropping their season average to 4.76.
During this same stretch, the Cardinals have averaged 2.6 opposition runs per game, lowering their season average to 3.91 runs per game.
The Milwaukee Brewers enter Wednesday’s game against the Cardinals with an 82-72 record (.532 winning percentage).
National League Central
The Brewers are second in the National League Central, 7.5 games behind the Cardinals, but are fighting the final National League Wild Card spot.
As of Wednesday, The Brewers are 1.5 games behind the Philadelphia Phillies for the final National League post-season berth.
The Milwaukee Brewers are 5-5 in their last ten games, averaging 4.8 runs per game, raising their season average to 4.76.
Over this same ten-game stretch, the Brewers have surrendered 3.6 runs per game to opposing hitters, dropping their season average to 4.32 runs per game.
According to MLB stats, the St. Louis Cardinals have won the head-to-head series 10-8, with one game remaining.
Of these sixteen games, only five have finished with a one-run spread. This information will be factored into our Cardinals vs Brewers prediction and your betting ticket.
Starting Pitchers
Jose Quintana as Starter
The St. Louis Cardinals have left-handed pitcher Jose Quintana scheduled to start Wednesday night’s matchup in Wisconsin. Quintana has a 6-6 record in thirty appearances, pitching to a 3.03 ERA and a 1.22 WHIP.
Of significant note for this Cardinals vs Brewers prediction, the Cardinals stats state they have won Quintana’s last five appearances, with three of these appearances finishing covering the run line spread and two games going into extra innings.
Brandon Woodruff as Starter
The Milwaukee Brewers have right-handed pitcher Brandon Woodruff scheduled to throw the first pitch against the Cardinals on Wednesday night. Woodruff has a 12-4 record in twenty-five appearances, pitching to a 3.18 ERA and a 1.09 WHIP.
The Brewers have won three of Woodruff’s last five appearances; his last three appearances, in fact. Only one of Woodruff’s previous five appearances has ended within a one-run spread.
Cardinals vs. Brewers Predictions and Picks
This game doesn’t matter to the St. Louis Cardinals. Unless players are playing for perforce bonuses, St. Louis won’t play a meaningful game until the post-season begins. However, Milwaukee needs every win and help from the rest of the team to win and sneak into the playoffs.
We like the favorable Brewers odds on the run line and are picking Milwaukee to win and cover the run line spread (-1.5) on Wednesday night in Milwaukee (+140 to +150).
Who to Bet On?
The Brewers and Cardinals have virtually split the head-to-head season series, and with St. Louis having clinched their playoff spot, this is the time for Milwaukee to take the final head-to-head matchup.
If we’re making one pick for our Cardinals vs. Brewers predictions today, we’re taking the Milwaukee Brewers to cover the run line spread (-1.5) (+140 to +150).
MLB Pick: Brewers -1.5 (+145)
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