NFL Picks

Carolina Panthers vs. New York Giants Best Bets

The Carolina Panthers (0-1) head to the Big Apple to take on the New York Giants (1-0) in NFL Week 2 of the NFL season. Check out below for our Giants vs Panthers best bets.

The Panthers are coming off a disappointing 26-24 loss to the Browns in Week 1. The Giants pulled off a surprising 21-20 win over the Titans in Week 1. Both teams will look to move up in the NFL standings this season.

Panthers vs. Giants Odds Breakdown

Panthers Current Odds

The Panthers (+2.5) are +110 underdogs. The Panthers are currently 0-1 against the spread this year and were 5-12 against the spread in 2021.

As fun as a Panthers game today can be, covering the spread just five times is never fun, so keep that in mind when making your Giants vs Panthers best bets.

Giants Current Odds

The Giants (-2.5) are -130 favorites. The Giants are currently 1-0 against the spread this year and were 6-11 against the spread in 2021. Daniel Jones is 13-25 as a starter against the spread as a starter.

Carolina Panthers


One of the biggest strengths of the Panthers’ offense comes from a healthy Christian McCaffery, who has only played 11 of the last 34 NFL games. 

McCaffery had a slower first game with ten carries, 33 yards, and a touchdown, so look for increased yards in Week 2.

Wide receiver Robbie Anderson led the team with five catches, 102 yards, and a touchdown. With eight targets, Anderson may be new QB Baker Mayfield’s new favorite target.

Playing against his former team last week, Baker Mayfield was 16/27 passing with 235 yards. He also passed for one touchdown and an interception. Look for more touchdowns going forward.


The Carolina Panthers‘ defense allowed 355 total yards in Week 1, with 217 coming from the run and 138 coming against passing plays. The Panthers will need to figure out their run defense struggles heading into this week.

The Panthers will need to clean up their penalties as they had eight for 96 yards in NFL Week 1.

New York Giants


The biggest strength for the Giants, like the Panthers, is a healthy running back in Saquon Barkley, who has missed 18 games over the past two seasons.

Barkley showed he was back to full strength in Week 1 with 18 rushing attempts for 164 yards and a touchdown. He also had six catches for 30 yards.

Giants’ Run Defense

The Giants’ run defense is known to be one of the few highlights of the defense, and it showed in Week 1 with just 93 yards against on 26 attempts.

Even Giants predictions didn’t see this, but Daniel Jones is one to keep an eye on as he had an 81% completion rate in Week 1 with 188 yards, one touchdown, and one interception. That isn’t a bad game for him, but it’ll be interesting to see if he keeps up.


The Giants’ secondary is the biggest struggle on defense, who allowed 266 yards against with 20-33 passes completed against in Week 1.

Kadarious Toney was left unseen in Week 1, who had zero targets in Week 1. The WR2 for the Giants will need to find a way to get himself open if he wants to see catches in Week 2.

Panthers vs. Giants Season Forecast

Carolina Panthers Season Forecast

With an upgrade at QB with the addition of Baker Mayfield and the hope for a healthy season from star RB Christian McCaffery, the Panthers should have a solid season.

Finishing with a 5-12 record in 2021, the Panthers hope they can surpass five wins this year and their current projected total of 6.5 wins.

With how they looked in Week 1, the offense is solid, but their defense will need to pick up their slack.

Giants Season Forecast

After too many times of getting it wrong, it appears the Giants finally got it right by hiring former Bills offensive coordinator Brian Daboll as their head coach after a surprising win in Week 1.

Pulling off an upset is never easy but doing it in the first game of the season is always nice for a team like the Giants, who won just four games in 2021.

An Interesting Offense with Barkley

With a healthy Barkley, things will be interesting for the offense, but until Daniel Jones finds consistency, the New York Giants‘ offense could still struggle.

With a projected seven wins this year, the Giants proved they are capable of that three win jump.

What To Expect From This Matchup?

With the over/under for this game set at 42.5, this game could be high-scoring and close with how these two teams played last week.

The Panthers will be in for some trouble with their run defense as they allowed 217 rushing yards against in Week 1 and will face Saquon Barkley, who went off for 164 in Week 1 for the Giants.

On the other side, the Giants will be in for some trouble against WR pair Robbie Anderson and DJ Moore. Anderson had 102 yards, while Moore had a quieter than normal 43 yards receiving.

Giants vs. Titans Prediction and Best Bets

With the Panthers losing a close game and the Giants winning a close game, these two teams could be headed in opposite directions than their Week 1 games.

The NFL injury report is quiet for both teams, so look for full-strength efforts. Giants vs Panthers best bets are based on last week’s results.

NFL Pick: Panthers +2.5 (-110)

NFL Pick: Panthers (+110)

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