The San Francisco 49ers are entering the 2022 NFL season with plenty of optimism, and you will be able to see that when looking at the 49ers season odds. San Francisco was in the NFC Championship a season ago and returned much of the same roster.
The 49ers are members of the NFC West Division, and that is arguably going to be the best division in football this season. San Francisco will have to play well, but there are a number of different ways to make NFL picks for this team in 2022.
San Francisco 49ers Week 1 Matchup Preview
Trey Lance is expected to take over as the starting quarterback for the 49ers, and this will be his first real test in Week 1.
The 49ers love to run the football, though, and that rushing attack and the terrific defense will play a key role in this game.
Justin Fields Second Year
Chicago will have a second-year quarterback Justin Fields leading the offense, but this team also has holes on both sides of the ball. The Bears are not expected to be very good in 2022, and it could lead to a pretty long season.
San Francisco 49ers should have no trouble against the Bears in Week 1 as they win in Chicago and cover the 4.5-point spread.
2022 San Francisco 49ers Schedule
- Week 1: at Chicago Bears
- Week 2: vs. Seattle Seahawks
- Week 3: at Denver Broncos
- Week 4: vs. Los Angeles Rams
- Week 5: at Carolina Panthers
- Week 6: at Atlanta Falcons
- Week 7: vs. Kansas City Chiefs
- Week 8: at Los Angeles Rams
- Week 9: BYE WEEK
- Week 10: vs. Los Angeles Chargers
- Week 11: vs. Arizona Cardinals
- Week 12: vs. New Orleans Saints
- Week 13: vs. Miami Dolphins
- Week 14: vs. Tampa Bay Buccaneers
- Week 15: at Seattle Seahawks
- Week 16: vs. Washington Commanders
- Week 17: at Las Vegas Raiders
- Week 18: vs. Arizona Cardinals
San Francisco 49ers Season Props
The 49ers season odds can be found for a number of different markets, including player and team prop betting options. You can also make a wager on the regular season wins for San Francisco, and the odds for that bet are below:
- Over 9.5 Wins (-145)
- Under 9.5 Wins (+125)
Getting to 10 wins would likely get the 49ers into the postseason, but it will take more than that to win the NFC West Division.
You can also take the 49ers at +2000 to have the best regular season record in the NFL, and that could be a realistic possibility.
If you want to bet on some player props for the 49ers, then you could look at the over/under for receiving yards for Deebo Samuel. Those betting lines are set at 925.5 yards, and the odds are at -115 for each side of that bet.
San Francisco 49ers 2022 Season Odds
49ers 2022 Super Bowl Odds
The San Francisco 49ers were just one win away from the Super Bowl during the 2021 season, despite not having the best NFL team stats in the league. San Francisco has a winning formula that continues to work, and that will be the same plan in 2022.
The odds to win the Super Bowl for the 49ers are currently set at +1600, and there are just five teams ahead of them. One of the teams, the Los Angeles Rams (+1100), are the defending Super Bowl champions and are also in the same division as San Francisco.
San Francisco 49ers Playoff Odds
It’s not a guarantee that the San Francisco 49ers are going to make the playoffs in 2022, but the odds favor them getting that done. San Francisco has odds set at -225 to reach the postseason this year, which means it would be a pretty big disappointment if they came up short.
49ers NFC West Odds
The NFL matchups in the NFC West should be fun to follow all season long, and three teams feel like they have a great shot at winning the division. San Francisco should be in the mix, but they won’t enter the season as the favorites.
Here are the future odds to win the NFC West Division in 2022:
- Los Angeles Rams +125
- San Francisco 49ers +200
- Arizona Cardinals +300
- Seattle Seahawks +1500
49ers NFC Championship Odds
Winning the NFC is a realistic possibility for the San Francisco 49ers this year, as they have the fourth-best odds to win the conference.
San Francisco has odds set at +750, just behind the Los Angeles Rams at +500. The Tampa Bay Buccaneers are the favorites to win the NFC this season, with odds set at +340.