Sunday in the National Football League will feature a pair of NFC West teams, as the San Francisco 49ers are at the Arizona Cardinals. This is a rematch of the game back in October where the 49ers smashed Arizona. The 49ers have won five straight games, and are the top seed in the NFC with their 10-3 mark.
49ers vs Cardinals Picks
- San Francisco 49ers -12.5
- UNDER 47.5
For Arizona, they come into the game with a 3-10 mark. The Cardinals beat the Pittsburgh Steelers in their last game, but are coming off a bye last week. In their previous matchup, the San Francisco 49ers beat the Arizona Cardinals 35-16 on October 1st, 2023. Let’s get to our 49ers vs. Cardinals picks and parlays!
San Francisco 49ers vs. Arizona Cardinals Odds
Before our NFL Expert Picks, take a look at the updated NFL Odds:
- Spread: San Francisco 49ers -12.5, Arizona Cardinals +12.5
- Total: 47.5
- Moneyline: San Francisco 49ers -800, Arizona Cardinals +550
San Francisco 49ers vs. Arizona Cardinals Picks & Parlays
Here are our updated 49ers vs. Cardinals picks and parlays!
San Francisco 49ers vs. Arizona Cardinals Pick
- San Francisco 49ers -12.5
The 49ers are going to win this game with ease. The offense will get to 30+ and there is no way the defense is going to let Arizona keep up anywhere close to that. The 49ers win this game by two or more touchdowns!
San Francisco 49ers vs. Arizona Cardinals Parlay
- San Francisco 49ers -12.5
- San Francisco 49ers / Arizona Cardinals UNDER 47.5
While we said the 49ers would get to 30+, Arizona is going to struggle to get to double figures. A touchdown and a field goal gets them there, but that’s it. The 49ers win this game 34-10 over the Cardinals, and the UNDER hits on our picks and parlays.
San Francisco 49ers vs. Arizona Cardinals Information
Take a look at some information for one of the NFL Matchups in Week 15:
San Francisco 49ers vs Arizona Cardinals
Date & Time: Sunday December 17th, 2023; 1:05 pm PST
Location of the game: State Farm Stadium; Glendale, AZ
How to Watch: CBS
San Francisco 49ers vs. Arizona Cardinals Betting Analysis
We all know the story of Brock Purdy by now, but the former Iowa State signal caller has been incredible. Purdy has over 3,500 passing yards, with 25 touchdowns and just 7 interceptions on the season. In the passing game, if they are not going to Brandon Aiyuk, or George Kittle or Deebo Samuel, it could be Christian McCaffrey.
The running back has been incredible both on the ground and in the pass game. McCaffrey has more than 430 receiving yards, with an additional 1,177 rushing yards as well. McCaffrey leads the NFL with 17 touchdowns.
The San Francisco 49ers schedule shows that they will host the Baltimore Ravens on Christmas Day. Then, on New Years Eve, they are at the Washington Commanders. The final game for the San Francisco 49ers is at home against the Los Angeles Rams.
Arizona has three wins on the season. A Week 3 win over the Cowboys, followed by later wins over the Falcons and Steelers have them sitting in a good spot for one of the top picks in the 2024 draft. What they do with that NFL draft pick is yet to be seen.
Kyler Murray has come back as the signal caller for Arizona. Murray has thrown for 864 yards and 3 touchdowns since his return. The Arizona offense ranks 26th in scoring with 17.7 points per game. The passing game is 30th with less than 173 yards per game, while they are 9th with 123 yards per game on the ground.
The Arizona Cardinals will play their next two games after this on the road. The Cardinals are at the Bears on Christmas Eve, and at the Eagles on New Years Eve. Then on January 7th, Arizona will host Seattle.
San Francisco 49ers vs. Arizona Cardinals Betting Picks
The bad news for Arizona is they are going to get smoked in this game. The good news is – they are close to getting a Top 5 draft choice. The Cardinals stand no chance here. They score a touchdown and a field goal but allow four touchdowns and two field goals.
The 49ers win this game, and win it easily. Bet on the San Francisco 49ers -12.5 and the UNDER 47.5, as Brock Purdy continues to help his MVP odds. Hope you enjoyed our 49ers vs. Cardinals picks and parlays!
Discover the latest stats and trends of this matchup here.
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