Arizona Cardinals vs. Carolina Panthers

In the NFC, the Arizona Cardinals entered the 2022 season with much higher expectations than the Carolina Panthers.

It will be up to the Cardinals to live up to those expectations in Week 4 of the NFL schedule, though, as they travel to Charlotte to take on the Panthers. 

With the Panthers looking to solidify the quarterback position this season, the Cardinals will have to step up defensively in this matchup to avoid being upset on the road.

Here, we will break down this Cardinals vs. Panthers matchup from a betting perspective. Bettors will find the necessary trends they need to make an informed wager on this game, along with previous Cardinals at Panthers stats to get an idea of how this series has unfolded in the past.

Rivalry History

When doing any sort of Cardinals at Panthers betting analysis, bettors should be aware of the history between these two teams.

 That history is a lopsided one, as the Panthers have had the Cardinals’ number in the 19 times they have played one another.

Carolina holds a 14-5 advantage in the all-time series between these teams, including a six-game winning streak that dates back to the 2015 postseason.

In games played in Carolina, the Panthers have had a huge advantage over the Arizona Cardinals as well. The Panthers have gone 8-3 all-time against the Cardinals in games they have hosted, including each of the last five such matchups.

The last time the Cardinals won in Carolina was the 2009 postseason when Jake Delhomme was the quarterback for the Panthers.

Matchup Trends

In looking at last season’s NFL stats, it is clear that the Arizona Cardinals were much better at covering the spread than the Carolina Panthers. 

Arizona went 10-8 against the spread last season, including a 10-7 record in the regular season. Carolina, meanwhile, was tied with the Jacksonville Jaguars as the worst NFL teams against the spread with a 5-12 record against the number.

When it came to totals in 2021, the Cardinals and Panthers both saw over half of their games go under the number. 

Arizona went 8-10 to the over a season ago, while the Carolina Panthers went 8-9 to the over. Of course, the potential for change at quarterback in Carolina could change how potent the Panthers offense is and could change how they perform relative to the total in 2022.

Venue Information

Bank of America Stadium is the home of the Carolina Panthers and the venue for this NFL Week 4 contest. Last season, the Panthers went 2-6 at home, with only the 2-7 Houston Texans performing worse on their home field.

While this should not be the be-all and end-all of any Cardinals vs. Panthers betting analysis, seeing how far down the NFL standings the Panthers were at home and against the spread is worth keeping in mind.

Betting Tips for Arizona Cardinals vs. Carolina Panthers

Any NFL matchups concerning the Carolina Panthers are loaded with intrigue during the 2022 NFL season, as the team has multiple starting quarterback options to choose from.

The NFL odds for this game will likely be determined by how those quarterbacks perform early in the season and which signal caller the Panthers use the most heavily early on. 

Those making NFL picks against the spread on this game will want to keep a close eye on the Carolina quarterback situation to try and gain an advantage on the betting markets.