Pittsburgh Steelers vs. Buffalo Bills

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The Steelers begin the second quarter of the 2022 season with a game at the Super Bowl favorite Bills.

Steelers vs. Bills Betting Preview

Pittsburgh has the reigning NFL Defensive Player of the Year in T.J. Watt, but when you look at the Steelers at Bills stats, this NFL matchup is still very much in favor of the Bills.

The Bills had the third-best scoring offense in football in 2021 at 28.4 points per game. The Steelers gave up 23.4 points per game, which was only good for the 20th. 

The NFL odds have Watt as a favorite again to DPOY, but they also have Bills quarterback Josh Allen as a favorite to win the MVP.

Rivalry History

As good as the Buffalo Bills were last season, they lost to the Steelers in the opening week of 2021, 23-16. The Steelers at Bills stats from that game were incredible. 

Buffalo outgained Pittsburgh 371-252 and ran 76 offensive plays to just 53 for the visiting Steelers, but Buffalo lost the game.

The Steelers lead the all-time series 17-11, which includes 2-1 in the postseason. The last playoff matchup came in 1996.

Matchup Trends

The early Steelers vs. Bills odds have the Bills as 8.0-point favorites. It makes sense when you look at the rest of the NFL odds concerning these two teams. 

The Bills are -225 to win their division, +300 to win the AFC, and +600 to win the Super Bowl. The Pittsburgh Steelers are +900 to win the AFC North, +4000 to win the AFC, and +8000 to win the Super Bowl.

Buffalo’s defense was one of the best in 2021, but they were vulnerable against the run. So when looking at the Steelers vs. Bills stats, the Najee Harris vs. the Buffalo run defense matchup is going to be one of the most important. 

Pittsburgh is starting a new quarterback, but Harris knows the offense well and is coming off a 1,200-yard rookie season.

The NFL schedule is also kind to the Steelers for this NFL Week 5 matchup. The Bills host the Steelers after a tough game against the Ravens. Pittsburgh is coming off what is seemingly an easier game against the Jets.

Venue Information

No doubt affecting the Steelers vs. Bills odds is the home-field advantage the Bills have when playing at Highmark Stadium in Buffalo. 

On hand will be 71,000 screaming fans who haven’t had this much optimism about their team since the 1990s. Highmark is one of the older stadiums in the league, first opening in 1973 as Rich Stadium.

Betting Tips for Pittsburgh Steelers vs. Buffalo Bills

Both of these NFL teams are regulars atop the NFL Standings, with the Bills having won the AFC East in each of the last two seasons and the Steelers having finished first in three of the last six years. They were in second place the other three years.

The Steelers at Bills stats that are most interesting heading into this game revolve around the new Steelers quarterback and how he is growing inside an offense built around someone other than Ben Roethlisberger. 

Plus, you’ll want to see how the Bills pass defense is doing and if cornerback Tre’Davious White is fully healthy after tearing his ACL last November.

Another stat that may influence the final Steelers at Bills odds and alter your NFL picks for Week 5 is how often Bills rookie running back James Cook is on the field. 

Buffalo feels like they got a great three-down back in this year’s draft, and if he can take some of the rushing load off Allen’s shoulders – especially on third down – the Buffalo offense could be even better in 2022.


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