San Francisco 49ers vs. Carolina Panthers

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The San Francisco 49ers and Carolina Panthers look to make their quarterback changes for this season pay off when they face one another in NFL Week 5 of the NFL season.

49ers vs Panthers Betting Preview

When the San Francisco 49ers and Carolina Panthers face off in Week 5, it will be one of the more intriguing NFL matchups of the week. With both teams making changes at the quarterback position ahead of this season, both teams will have offenses worth keeping an eye on here. 

Combine the quarterback intrigue with the defending NFC champions going East for a road game, and this contest could go in any number of directions.

In this 49ers at Panthers betting analysis, bettors will find out what they need to know before San Francisco 49ers and Carolina square off. 

That includes the latest betting trends for both teams and the history between them going into this Week 5 contest. That way, bettors can make the most informed decisions possible going into the game.

Rivalry History

Despite the San Francisco 49ers being one of the most historically successful NFL teams of all time, the Carolina Panthers have had the all-time edge against them. 

Carolina has gone 13-9 all-time against the 49ers, though San Francisco won their last meeting in a big way. That came in 2019 when the 49ers beat the Panthers by a score of 51-13.

Looking at the 49ers vs. Panthers stats specifically, the Panthers hold a slim 6-5 advantage over the 49ers in games played in Carolina. 

San Francisco has not played on the road against the Panthers since the 2016 season. Carolina won that game by a convincing margin of 46-27, a result they will look to replicate when these teams meet in Week 5 of the 2022 campaign.

Matchup Trends

Looking at the NFL stats from last season, it is clear that the 49ers have an advantage over the Panthers coming into 2022. San Francisco was one of the best teams at covering the spread a season ago, going 12-8 against the number between the regular season and playoffs. 

Carolina, meanwhile, was tied for the worst ATS record in the league with a 5-12 record against the spread in their 17 regular season contests.

Both of these teams saw the majority of their games go under the total during the 2021 NFL season. Carolina Panthers went 8-9 to the over in 2021, with a slight majority of their games going under.

San Francisco, meanwhile, had 12 of their 20 games go under the total as their defense was stout during the second half of the season.

Venue Information

When this game unfolds in Week 5 of the NFL schedule, it will do so at Bank of America Stadium in Charlotte. Early last season, the Panthers had some success at home, with their win over the New Orleans Saints in Week 2 being one of the more impressive of the season. But the Panthers will need more performances like that at home if they want to improve in 2022.

Betting Tips for San Francisco 49ers vs. Carolina Panthers

While any 49ers at Panthers betting analysis will tell you that the 49ers are the better team right now, there is a lot more to winning in the NFL than being the better team. 

While the Niners are expected to finish higher in this year’s NFL standings, those making NFL picks against the spread will want to keep an eye on how both teams adjust to their quarterback changes before placing any wagers. 

The NFL odds for this contest will likely depend on how both offenses perform, with Trey Lance and Baker Mayfield at the helm through the first month.

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