San Francisco 49ers vs. Denver Broncos

There are a number of great betting storylines revolving around the 49ers vs. Broncos odds. The Broncos were a fourth-place team last year, but because of the addition of quarterback Russell Wilson, they are the eighth most likely Super Bowl winner, paying +1600, according to NFL odds.

The 49ers, also with a new quarterback this season, are just ahead of the Broncos at +1560. The other 49ers at Broncos odds to keep a watch for is the MVP race. 

Wilson is paying +1500 to win the MVP award, just behind Rams quarterback Matthew Stafford. New San Francisco 49ers starting quarterback Trey Lance is paying +5000, just behind Cooper Kupp and Jonathan Taylor.

Rivalry History

As teams in different conferences, there isn’t a natural rivalry between the 49ers and Broncos, but these two teams do have a history against one another. 

They played each other in Super Bowl XXIV, and it was the biggest blowout in the history of the Super Bowl, a 55-10 49ers victory. Joe Montana threw for 297 yards and five touchdowns, and John Elway threw for 108 yards and two interceptions.

In 15 all-time meetings, the 49ers lead the series 8-7, according to NFL stats. This should be an excellent NFL matchup, as both teams are usually competitive in the NFL standings.

Matchup Trends

The early 49ers vs. Broncos odds have Denver as a 2.5-point favorite. There are interesting 49ers at Broncos stats to examine, considering that both teams are rolling out a new starting quarterback this season.

Last year with Jimmy Garoppolo as their primary signal caller, the 49ers finished as the 12th best passing team in the league. 

They then parlayed that into playoff wins at Dallas and Green Bay, making it to the NFC Championship Game. That’s not much room to improve for Trey Lance.

With Teddy Bridgewater as their primary signal caller in 2021, the Denver Broncos ranked 20th in the NFL and lost their final four games of the year, and finished in last place. So there is plenty of room for improvement with Russell Wilson as their quarterback.

Venue Information

The Broncos play their home games at Empower Field at Mile High, located in downtown Denver. It replaced the original Mile High Stadium in 2001 and has an NFL seating capacity of 76,125. 

Every game played at Empower Field since it opened has been sold out, continuing a sold-out streak in Denver that dates back to 1970. The Broncos enter the 2022 season with a 105-64 record at Empower Field.

Betting Tips for San Francisco 49ers vs. Denver Broncos

The 49ers vs. Broncos odds were released as soon as this game was announced on the NFL schedule, but as both teams have advanced to the regular season, the excitement for both teams has risen.

The 49ers are one of the trendy NFL teams, and NFL picks to win the Super Bowl for a couple of reasons. They were within a field goal of the eventual Super Bowl-champion Rams in the NFC Championship Game last season, and the move to Trey Lance should only make their great running game even better. 

The Broncos are a trendy NFL pick because of one of the top secondaries in the league, a collection of dangerous wide receivers, and the addition of a Super Bowl-winning quarterback in Russell Wilson.

The 49ers at Broncos stats at quarterback are important, but the continued development of young running back Javonte Williams vs. the established running game of the 49ers will go a long way toward deciding this outcome. Keep this in mind when making NFL picks against the spread