Heading into NFL Week 2, the San Francisco 49ers take on the Seattle Seahawks at home in this division rivalry matchup. The 49ers hope to get back to .500 with a win which would give the Seahawks their first loss of the year. Check the 49ers vs Seahawks betting picks below.
The 49ers are looking for their first win against Seattle since NFL Week 17 of the 2019 season, and we have all you need to know about 49ers vs. Seahawks betting picks in this Week 2 matchup.
49ers vs. Seahawks Betting Picks and Predictions
Seahawks vs. 49ers Matchup Information
This game will be played in Santa Clara at Levi’s Stadium on Sunday at 4:05 p.m. EST.
The Seahawks are 1-0, while the 49ers are 0-1 against the spread this season. The breakdown and analysis of 49ers vs. Seahawks betting picks can be found below.
Seattle Seahawks
The Seattle Seahawks are heading into Week 2 following a shocking win and now look to keep things going on the road. The Seahawks game today shows they are doing fine without Russel Wilson and Bobby Wagner.
The Seahawks lost some key players over the offseason, which didn’t show in their first game. Geno Smith helped lead the offense while the defense as a whole played shut down against one of the better offenses in the league.
Key Injuries
- Kenneth Walker III (probable)
- Tyler Ott (questionable)
- Alton Robinson (injured reserve)
Can guys like DK Metcalf and Tyler Lockett get into the action with Geno Smith? Can the Seahawks’ defense continue playing this well? These will be answered in our 49ers vs. Seahawks betting picks.
Betting Trends to Know
When looking at the latest trends for the Seattle Seahawks and with just one game into the season, we will be using statistics from last year’s games and games that featured Geno Smith, as he is currently the starter for the Seahawks.
Last year, the Seahawks ranked 11th in the NFL with 122 rushing yards per game and ranked 23rd with 201.9 passing yards per game.
Seahawks Defense Rankings
On defense, the Seahawks were ranked second-worst with 265.5 passing yards allowed per game and ranked 17th in rushing yards against 113.6 per game.
Geno Smith was 2-3 last year and finished with 175.5 passing yards per game. Smith also averaged one touchdown per game and threw just one interception.
San Francisco 49ers
The San Francisco 49ers head into Week 2 looking to turn things around following their Week 1 loss to the Bears. Trey Lance started in his third career game, all without 49ers impact player TE George Kittle.
The 49ers, unfortunately, lost their starting RB Eli Mitchell to injury, with his replacement still uncertain.
With the upcoming 49ers’ schedule, they will need to clean up their act heading into some difficult weeks to come. Continue reading to find out what the 49ers are in for with our 49ers vs. Seahawks betting picks.
Key Injuries
- George Kittle (questionable)
- Eli Mitchell (doubtful)
- Daniel Brunskill (questionable)
Betting Trends to Know
Similar to what we noted about the Seahawks, the 49ers’ trends are based on last year’s games and games that featured Trey Lance. The 49ers finished 10-7 in the NFL standings in 2021.
In 2021, the 49ers ranked 12th in the NFL last season with 261 passing yards per game and ranked seventh with 127.1 rushing yards per game.
49rs Defense Rankings
On defense, the 49ers were ranked sixth-best with 214.4 passing yards allowed per game and ranked seventh-best in rushing yards against 103.5 per game.
Looking at Trey Lance’s NFL player stats, he started in two of six games he played and finished with five TD’s and two interceptions. Lance averaged 100.3 passing yards per game and had 130 rushing yards in his two starts on 23 attempts.
San Francisco 49ers vs. Seattle Seahawks Odds
With things possible to change depending on the status of Eli Mitchell, the San Francisco 49ers are currently favored -430 on the moneyline and -9.5 on the spread.
The Seattle Seahawks are underdogs at +328 on the moneyline and +9.5 on the spread. The over/under for the 49ers vs. Seahawks matchup is set at 42.5 with odds of -110 either way.
49ers vs. Seahawks Betting Picks
For a moneyline bettor to win, they would need the team they bet on to win the game outright. To use this game as an example, if a bettor wants to win $100 and bet the 49ers with their -430 odds, they would need to bet $430.
The over-under is determined by how many points are scored in the game. For example, with this game listed at 42.5 total points, we would need both teams to have over 43 points combined for the over to win and under 42 points for the under to win.
San Francisco 49ers vs. Seattle Seahawks Score Prediction
Regardless of Eli Mitchell’s status, I believe the 49ers will bounce back after their Week 1 loss and give their home fans a win. This game could see a 24-14 with the 49ers sending Seattle back home with an 0-2 record.
Who to Bet On?
The best bet heading into this game is the 49ers on the spread at -8.5. Although they haven’t beat the Seahawks since Week 17 in 2019, the 49ers are the better team, even with their current NFL injuries.
This is an excellent spot for them to break their cold streak against Seattle as Trey Lance looks to prove he is worth the starting QB job.
Although they pulled off a surprise upset in Week 1, Seattle still has some things to work on, and the 49ers are the team to expose it as they look for their first win against Seattle in two years.
The Geno Smith magic will eventually run out, and the 49ers are the team to back.
NFL Pick: 49ers -8.5 (-110)
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