The Dallas Cowboys are set to visit the Los Angeles Chargers on Monday Night Football in what should be a big game. The league always tries to deliver big games in primetime, and they have succeeded with this matchup.
Cowboys vs Chargers Picks

Los Angeles Chargers +110
Not only will this game provide some great entertainment, but you are going to find great betting options as well. There are a number of Cowboys vs Chargers betting picks to make in this game according to the odds that are listed.
Dallas Cowboys vs. Los Angeles Chargers Odds
Before you go and make some Cowboys vs Chargers betting picks on Monday night, you are going to need to check out the NFL odds. There are hundreds of different odds for all of the NFL matchups, but a few betting options stand out.
The Cowboys are two-point betting favorites in this huge game on the NFL schedule. You can also look at betting the over/under in this game, and that line is set at 51.0 total points.
Cowboys vs. Chargers Information
Dallas Cowboys vs Los Angeles Chargers
Location of the game: SoFi Stadium. Los Angeles, CA.
Date & Time: Monday, October 16. 8:15 PM ET.
How to watch: ABC | ESPN
Dallas Cowboys vs. Los Angeles Chargers Analysis
Dallas Cowboys Performance Recap and Analysis
The Dallas Cowboys are still in a good position in the NFL standings, but they can’t afford to lose any more games. Dallas just gave up 42 points in their most recent game, and that defense will be tested in this one.
Quarterback Dak Prescott also has some serious pressure on him to perform, as he has thrown just five touchdowns to four interceptions this season.
Key Injuries
The Dallas Cowboys roster has already been hit hard by injuries this season, especially on defense. A recent injury will keep linebacker Leighton Vander Esch off of the field in this game.
Betting Trends to Know
- The NFL team stats for the Cowboys have been all over the place this season.
- Dallas has gone 3-2 against the spread this season, with all of those covers coming in games that they have won.
Los Angeles Chargers Performance Recap and Analysis
Justin Herbert has some great NFL player stats yet again for the Chargers, as he has thrown for 1,106 yards and seven touchdowns this season. Los Angeles wants to throw the football a ton, and that has made them a tough team to defend.
Key Injuries
The NFL injury report doesn’t list quarterback Justin Herbert, but he is going to be dealing with a finger injury in this game. Los Angeles had a chance to get healthy as they had a bye in Week 5.
Betting Trends to Know
- The Chargers have gone 2-2 ATS so far this season, and that’s the same as their overall record.
- Los Angeles has played in two straight games that have actually gone under the point total.
Cowboys vs. Chargers Betting Picks
Here is a look at some of the best Cowboys vs Chargers betting picks that you might want to consider making on Monday Night Football.
- Moneyline (Chargers +110): This Los Angeles Chargers game is going to provide them a great opportunity to come away with a huge upset in this one. Los Angeles will get that done in this matchup.
- Over/Under (Over 51.0): Betting the over/under is always one of the best NFL picks to make, and this is going to be a high-scoring affair. Take the over 51.0, as this game will feature a ton of big plays.
- Spread (Chargers +2.0): Since the best bet to make in this game is to take the Chargers to win outright, then you also want to take them on the spread as well. Don’t pass up on the free two points in this game.
Dallas Cowboys vs. Los Angeles Chargers Prediction
While you can go a number of different ways with betting on this game, you want to try to get the most value. That is going to come by taking the upset in this one, as the Los Angeles Chargers will come away with a big win.
- NFL Pick: Los Angeles Chargers +110
Discover the latest stats and trends of this matchup here.
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