Sunday Night Football in Week 6 will feature the New York Giants visiting the Buffalo Bills. This isn’t really a big rivalry in the state of New York, but this will be a big game for each team.
Giants vs Bills Picks

- NFL Pick: Bills at -14.0 to cover the spread
Every NFL game tends to provide some great betting options, and that’s especially true in this matchup. Here is a look at some Giants vs Bills betting analysis that should help you make some wise betting picks for this game.
New York Giants vs. Buffalo Bills Odds
Giants vs. Bills Information
New York Giants vs Buffalo Bills
Location of the game: Highmark Stadium. Orchard Park, NY.
Date & Time: Sunday, October 15. 8:20 PM ET.
How to watch: NBC
Recent Scores
- Looking at recent scores for each team is important when putting together some Giants vs Bills betting analysis. The New York Giants football schedule has been difficult to begin the year, and they are coming into this game with a record of 1-4.
- Buffalo has had an interesting NFL schedule to begin the year, and their NFL Week 5 game was actually played in London. The Bills dropped that game to the Jacksonville Jaguars and enter this matchup at 3-2 on the year.
New York Giants vs. Buffalo Bills Betting Analysis
Giants Searching for Offense
New York doesn’t have any good NFL player stats this year, especially when it comes to the offensive side of the football. The Giants are averaging just 287 yards of total offense per game, and they struggle to do much of anything with the football.
Quarterback Daniel Jones has led an offense that has thrown for just 195 yards per game, and they are gaining just 92 yards per game on the ground. The defense has allowed 393 yards per contest, but that unit has been on the field way too often.
Bills Need to Defend
Quarterback Josh Allen and wide receiver Stefon Diggs both have solid NFL MVP odds this season. And that duo continues to put up big numbers. Allen has thrown for 1,407 yards this season, and Diggs has 520 receiving yards and five touchdowns.
There is no doubt that Buffalo has solid NFL team stats on offense, but the same can’t be said for the defense. Buffalo is allowing 134 rushing yards per game. And they have to find a way to improve upon that number as the season rolls along.
Updates
You will want to keep an eye on the NFL injury report this weekend to see the status of Daniel Jones. The New York Giants quarterback has joined running back Saquon Barkley on the injured list. The Buffalo Bills injury report is pretty clean for this game, and that is important to note.
Giants vs. Bills Betting Preview
The Bills are coming into this game as 14.0-point betting favorites and that’s an extremely large spread for an NFL game. The over/under for this matchup is set at 45.0 total points. And that takes into account how each team has fared this season.
New York is going to be playing some desperate football in this game, but they are also coming into this matchup extremely overmatched. Buffalo is in a position in which they can’t afford any more losses. And they will be focused on taking care of business in this one.
New York Giants vs. Buffalo Bills Betting Prediction
It’s pretty clear that Buffalo is the best overall team when looking at this Giants vs Bills betting analysis. New York would be able to keep it close if they were at full strength. But this is one of the NFL matchups that could end up getting out of hand in a hurry.
The Giants are currently buried in the NFL standings in the NFC East. And things are going to go from bad to worse in this matchup. Bet on the Bills at -14.0 to cover the spread as they roll to a blowout win over New York.
- NFL Pick: Bills at -14.0 to cover the spread
Discover the latest stats and trends of this matchup here.
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