San Francisco 49ers vs Chicago Bears

One of the more interesting NFL in Week 1 matchups of the season will take place in Chicago between the San Francisco 49ers and Chicago Bears. 

While the 49ers were vastly better in last year’s NFL standings, both teams feature young quarterbacks that will be worth keeping an eye on in 2022.

In our 49ers vs. Bears betting analysis, bettors will find out about the history of this matchup and what they should be aware of ahead of this matchup to make the best NFL picks possible for this game.

Rivalry History

When looking at 49ers vs Bears stats all-time, it is clear that this matchup has been evenly matched historically. The 49ers lead the all-time series between these teams by a 35-32-1 margin, with the recent history of this matchup being relatively even as well. 

These teams have alternated wins and losses against one another for each of their last seven meetings dating back to 2012.

The most recent matchup between the San Francisco 49ers and Bears took place in 2021, with the Niners winning that game 33-22. San Francisco racked up 322 passing yards in that game, compared to just 148 yards through the air for Chicago. The Niners will look to maintain that advantage in this matchup.

Matchup Trends

Before the 49ers and Bears face off in the first game of their NFL schedule, it is worth performing some 49ers vs Bears betting analysis.

 Last season, the 49ers went 9-8 against the spread in the regular season and went 3-0 against the spread in their three playoff games. 

Chicago, meanwhile, finished with the third-worst record in the league against the spread by going 6-11 against the number in 2021.

Both the 49ers and Chicago Bears saw the majority of their regular season games go under the total in 2021. San Francisco went 9-8 to the under last season, while Chicago went 10-7 to the under over that same time frame.

With both teams boasting quality defenses, a low-scoring game is possible here as well, though these teams combined for 55 points and an over last year.

Venue Information

Soldier Field will be the venue where these NFL teams meet in 2022, as these historic NFC teams will meet at one of the most historic NFL venues. 

As far as 49ers vs Bears stats are concerned, Soldier Field was not kind to the Bears last season, as they went 3-5 at home last year. San Francisco, meanwhile, went 6-3 away from home, including its victory at Soldier Field in October of 2021.

Betting Tips for San Francisco 49ers vs. Chicago Bears

Any 49ers vs Bears betting analysis has to acknowledge that this contest will come down to the quarterback play of both teams. 

NFL odds have the 49ers as favorites going into Week 1, with last year’s NFL stats positioning the 49ers as the superior offensive team by a wide margin. But Trey Lance is still inexperienced as an NFL quarterback, and there is a chance the Bears could slow him down.

Last season, when these two teams met, Jimmy Garoppolo was the quarterback for the 49ers. He was very effective in that game, averaging 11.5 yards per pass attempt. 

Lance has yet to have a consistent breakthrough as a passer, which will give the Bears a chance to keep the 49ers’ offense in check and steal a game over last year’s NFC runners-up in their season opener.