The Houston Astros and Chicago Cubs will continue their interleague series on Wednesday night at Wrigley Field in Chicago. The Cubs won the series opener 7-2 and can win the series with one more win.
Astros vs Cubs Picks

- Pick 1: Over 7.5 Runs
- Pick 2: Chicago Cubs -115
This should be one of the better games on the MLB schedule as both teams should be playoff contenders. Here is a look at some Astros vs Cubs betting predictions that should be made on Wednesday night.
Houston Astros vs. Chicago Cubs Information
Houston Astros vs. Chicago Cubs
Location of the game: Wrigley Field, Chicago, Illinois
Date & Time: Wednesday, April 24th, 7:40 PM ET
Where to Watch: Marquee Network
Houston Astros vs. Chicago Cubs Odds
To make some Astros vs Cubs betting predictions for Game 2 of the series on Wednesday night, it will be important to check out the betting odds. This could be one of the best on the MLB schedule today as the moneyline odds are tight.
Chicago is a slight moneyline betting favorite at -115, while those odds for the Astros are at -105. The over/under for this game is set at just 7.5 runs, which is one run less than Tuesday night’s total.
Houston Astros vs. Chicago Cubs Betting Preview
This has been a miserable start to the season for the Astros win rate, a team many thought could be the best team in the MLB by the end of the year. Houston is now sitting at 7-17 on the year, and starting pitching has done this team in throughout the year.
The Astros now have a team ERA of 5.16 on the year, and that’s just not giving the offense a chance to find a way to win games. Houston is still hitting .263 with 25 home runs, but they need pitching to get things figured out.
Chicago has been a team to check out when making MLB best bets this season as they are sitting at 14-9 through the first 23 games of the year. Chicago has a team ERA of 4.03, and that number would be better if the bullpen didn’t blow so many leads.
Michael Busch is having a big season leading the team with six home runs and a .292 batting average. The Chicago Cubs belted three home runs in the series opener, and they have plenty of power in that lineup.
Starting Pitchers
Spencer Arrighetti
Spencer Arrighetti will be on the mound for the Houston Astros in this game, but he has really struggled to begin the year. Arrighetti currently has an ERA that is sitting at 11.57 and he has yet to win one of these two starts.
Jameson Taillon
Jameson Taillon got a late start to the year as he was battling an injury, but he was extremely sharp in his first start. Taillon is now 1-0 with a 1.80 ERA on the year, additionally, he is a veteran pitcher who has had a ton of success throughout his career.
Will It Be a Pitching Duel or a Slugfest? Live Scores & Betting Odds at Insider’s Betting Digest!
Houston Astros vs. Chicago Cubs Picks and Predictions
There are a couple of Astros vs Cubs betting predictions that stand out in this matchup after looking at each team and the starting pitching matchup. This should be one of the best MLB games today as both lineups are loaded with some star power.
Houston just hasn’t been playing good baseball to begin the year, whereas the opposite has been true for the Chicago Cubs. The Astros will not have a great starting pitcher on the mound, and the Cubs offense should do some damage.
When making MLB picks and parlays for this game, Cubs -115 and over 7.5 are the best Cubs game bets.
- Pick 1: Over 7.5 Runs
- Pick 2: Chicago Cubs -115
Discover the latest stats and trends of this matchup here:
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