AL Central rivals are set to meet up on Thursday afternoon as the Cleveland Guardians will visit the Minnesota Twins. This will be the first game of a weekend series, and these two teams are expected to battle it out for the division title.
Guardians vs Twins Picks

- MLB Pick: Minnesota Twins -150
Even though these two MLB teams are extremely even, that doesn’t mean that every matchup is going to play out that way. Here is a look at some of the best Guardians vs Twins betting picks to make on Thursday afternoon.
Cleveland Guardians vs. Minnesota Twins Odds
When looking to make Guardians vs Twins betting picks, it will be important to check out the betting odds that are set for this game. Look for the Twins to take this game. They are the moneyline favorite at -150, while the Guardians sit at +130. Looking at the over/under is important when making MLB picks and parlays and that betting line is set at 7.5 total runs.
Cleveland Guardians vs. Minnesota Twins Information
Cleveland Guardians vs. Minnesota Twins
Location of the game: Target Field, Minneapolis, MN
Date & Time: Thursday, April 4, 4:10 PM ET
How to Watch: MLB Network
Cleveland Guardians vs. Minnesota Twins Analysis
Taking a close look at Cleveland Guardians vs Minnesota Twins match player stats is another way to make predictions on this game.
Guardians Performance Recap and Analysis
The Cleveland Guardians are off to a great start this year. That includes a tough trip to Seattle. Cleveland has been getting great work from the pitching staff as the team ERA is sitting at just 2.51 ahead of this game.
Jose Ramirez is once again leading the way on offense as he has a home run and six RBIs through the first seven games of the year. This Cleveland team doesn’t have a ton of power, but they can string hits together.
Key Injuries
Right fielder George Valera is currently on the 7-day IL, but the rest of the Guardians lineup should be ready to go in this game.
Betting Trends to Know
- The Guardians have yet to play a home game this season, and they are 5-2 overall.
- The Guardians have won each of their last three games by at least three runs.
Minnesota Twins Performance Recap and Analysis
The Minnesota Twins are going to have to figure out a way to be better on offense as this team is hitting just .211 so far this season. Minnesota has also belted just two home runs and they will need to find more power.
The Twins have been getting great work from the starting rotation, and they will have Pablo Lopez making the start on Thursday.
Key Injuries
The Minnesota Twins only list pitchers on the IL, and there aren’t any of their star pitchers that would impact this game.
Betting Trends to Know
- All three of the Minnesota Twins wins this season have come by at least three runs.
- They are also 0-0 at home so far.
Cleveland Guardians vs. Minnesota Twins Betting Picks
Here is a look at three potential Guardians vs Twins betting picks that you will want to make in this series opener.
- Moneyline (Minnesota Twins -150)
Taking the Twins at -150 is one of the MLB best bets today as they should pick up a win in their home opener.
- Over/Under (Over 7.5)
This won’t be one of the highest-scoring MLB games of the season, but taking the over 7.5 runs is the way to go in this one.
- Spread (Cleveland Guardians +1.5)
Don’t underestimate the Guardians! The +1.5 run line could be a winning bet.
Cleveland Guardians vs. Minnesota Twins Prediction
It will be interesting to make a Guardians vs Twins prediction all season long as these teams will battle it out all year. Cleveland is off to a better start this season, but playing in the home opener should give the Twins a nice boost.
The MLB schedule is a bit light on Thursday, but this game will come with some excitement. Taking the Twins at -150 is the best betting pick that should be made when looking at the series opener.
- MLB Pick: Minnesota Twins -150
Discover the latest stats and trends of this matchup here:
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