The Penn State Nittany Lions will take to the road and battle the Ohio State Buckeyes on Saturday in a Big Ten showdown. Both teams come into the game without a loss on the season. The Nittany Lions are ranked 7th in the latest Associated Press Top 25 poll. Penn State Nittany Lions is 6-0 on the season and coming off the shut-out win over UMass. For Ohio State, they are also 6-0 and won their last game on the road at Purdue. The Buckeyes are ranked 3rd in the nation.
Penn State vs Ohio State Picks

Bet on Penn State spread +3.5.
Let’s get some more information on both teams and give our Penn State vs Ohio State prediction. Looking at the college football standings, we should be in for an exciting game!
Penn State Nittany Lions vs. Ohio State Buckeyes Odds
Penn State Nittany Lions vs. Ohio State Buckeyes Information
Take a look at some of the information on the NCAAF schedule between two of the top NCAA Football teams in the country:
Penn State Nittany Lions vs Ohio State Buckeyes
Date & Time: Saturday October 21st, 2023; 12:00pm EST
Location of the game: Ohio Stadium; Columbus, OH
How to Watch: FOX
Penn State Nittany Lions vs. Ohio State Buckeyes Recent Scores
In their previous matchup, Ohio State Buckeyes beat Penn State 44-31 back on October 29th, 2022.
Penn State Nittany Lions 2023 Results:
- Saturday, September 2nd, 2023: 38-15 win over West Virginia Mountaineers
- Saturday, September 9th, 2023: 63-7 win over Delaware Blue Hens
- Saturday, September 16th, 2023: 30-13 win at Illinois Fighting Illini
- Saturday, September 23rd, 2023: 31-0 win over Iowa Hawkeyes
- Saturday, September 30th, 2023: 41-13 win at Northwestern Wildcats
- Saturday, October 14th, 2023: 63-0 win over UMass Minutemen
Ohio State Buckeyes 2023 Results:
- Saturday, September 2nd, 2023: 23-3 win at Indiana Hoosiers
- Saturday, September 9th, 2023: 35-7 win over Youngstown State Penguins
- Saturday, September 16th, 2023: 63-10 win over Western Kentucky Hilltoppers
- Saturday, September 23rd, 2023: 17-14 win over Notre Dame Fighting Irish
- Saturday, September 30th, 2023: 37-17 win over Maryland Terrapins
- Saturday, October 14th, 2023: 41-7 win at Purdue Boilermakers
Penn State Nittany Lions vs. Ohio State Buckeyes Betting Analysis
Before our Penn State vs Ohio State prediction, take a look at the most up-to-date NCAAF Odds:
- Spread: Ohio State Buckeyes -3.5, Penn State Nittany Lions +3.5
- Total: 46.5
- Moneyline: Ohio State Buckeyes -185, Penn State Nittany Lions +155
Penn State Nittany Lions vs. Ohio State Buckeyes Betting Preview
Nittany Lions Locked and Loaded
James Franklin and his Nittany Lions feel they are more than ready for this game. The Nittany Lions have not been tested for several weeks and are ready for some competitive action. Penn State, on the season, is scoring 44.3 points per game and allowing just eight per game. The Nittany Lions defense ranks second in College Football in points allowed.
On the offensive side, the Nittany Lions love to run the football. Kaytron Allen is the top rusher for the team, with 375 yards and three touchdowns. The Nittany Lions as a team are averaging more than 203 yards per game on the ground. Penn State’s quarterback Drew Allar has been strong, with 12 passing touchdowns, including three of them to KeAndre Lambert-Smith.
The Nittany Lions take on Indiana and then at Maryland after this, before their next big showdown, this time at home, against Michigan. The Penn State Nittany Lions standings in the Big Ten, and even in the national rankings, are up for grabs in this game and in a couple of weeks.
Ohio State’s Air Attack Dominance
The Ohio State Buckeyes, led by head coach Ryan Day, have seen plenty of these types of games over the last couple of seasons. During this season, the Buckeyes went right to the wire on the road at Notre Dame. That was the lone score this season for the Buckeyes within a score.
On the season, Ohio State Buckeyes stats show they are scoring 36 points per game, and defensively, they are just behind Penn State, allowing 9.7 points per game. Offensively, Kyle McCord is having a big season under center.
His top target, Marvin Harrison Jr, has emerged as one of the top receivers in the country, with 604 yards and five touchdowns. Looking at more of their college football players, we can see that McCord’s leading the offense to 15th in the country with 308 yards via the pass per game.
Ohio State has back-to-back road games at Wisconsin and Rutgers to follow this game.
Penn State Nittany Lions vs. Ohio State Buckeyes Betting Prediction
We expected a great College Football game. Maybe the best of the weekend. The Penn State Nittany Lions do not get a ton of publicity, but they are tough, physical, and talented.
This is going to be a game that goes back and forth. Look for both teams to allow double digits in this game, but not too much more. In the end, the Buckeyes use a late field goal to win this game at home, but that gives the Nittany Lions the cover.
Barring any late additions to the college football injury report, take Penn State +3.5 over Ohio State on Saturday.
- Pick: Penn State to cover the spread (+3.5)
That is our final Penn State vs Ohio State prediction! Hope you enjoy all our NCAAF Picks for the NCAA Football games today!
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