The Cleveland Browns and Indianapolis Colts are set to play on Sunday at Lucas Oil Stadium in Indianapolis.
Browns vs Colts Picks

- NFL Pick: Take the Browns -2 and bet on the under
The Cleveland Browns come into the game with a 3-2 record and in the middle of a competitive fight for the lead in the AFC North. Cleveland came away with a massive home win over the 49ers last week.
For Indianapolis, they lost their second game of the season to Jacksonville last week. The Colts are now 3-3 on the season.
Let’s get to our Browns vs Colts betting picks. Looking at the NFL standings, we should be in for a great game!
Cleveland Browns vs. Indianapolis Colts Odds
Take a look at the NFL Odds for one of the many NFL Matchups for Sunday:
Browns vs. Colts Information
Before our Browns vs Colts betting picks, take a look at some information for this game on the NFL Schedule:
Cleveland Browns vs Indianapolis Colts
Location of the game: Lucas Oil Stadium. Indianapolis, IN.
Date & Time: Sunday, October 22. 1:00 pm EST.
How to watch: CBS
Cleveland Browns vs. Indianapolis Colts Analysis
The Cleveland Browns won a massive game over the San Francisco 49ers that gave them their first loss of the season. The Browns got a little luck with a missed field goal as time expired to win the game. But, the win was especially huge with the absence of DeShaun Watson, who missed his second straight game on the NFL Injury Report. PJ Walker got the start for the Browns.
Walker did the job for the Browns. He threw for 192 yards but did not throw a touchdown in the game. He did throw two interceptions as well. His top target was Amari Cooper, with 108 yards. Cooper now has 367 yards and a touchdown on the season. Elijah Moore is next for Cleveland with 21 receptions and 167 yards. His NFL MVP odds are slim.
The Browns are also without their top running back, Nick Chubb. He will miss the remainder of the season. Jerome Ford has taken over the running back spot with 270 yards on 67 carries and a touchdown for his NFL Player Stats. The Cleveland Browns schedule shows this as a road game and another road game at Seattle next week.
Colts’ Running Game Boosted
Another team without their starting quarterback is the Indianapolis Colts. Anthony Richardson is out, and Gardner Minshew is in. Minshew had a horrific game on Sunday, throwing three interceptions and getting sacked three times.
Jonathan Taylor has returned for the Indianapolis Colts following his hold out the first four games. But Zack Moss still continues to be effective for the Colts run game. Moss has 466 yards and four rushing touchdowns this season. Indianapolis ranks 15th in league with 116.7 rushing yards per game. Overall, Indianapolis is scoring 23.3 points per game.
The Colts will play this game at home and then welcome New Orleans next week. Following that, the Colts have a trip to Carolina and a home game against the Patriots before their bye week.
The Indianapolis Colts odds are not as good without their star rookie quarterback Anthony Richardson, really, no matter how good Minshew is or is not.
Browns vs. Colts Betting Picks
The Cleveland Browns defense may be the best in the National Football League. Sure, the NFL Team Stats may not approve of that, but they have been great to start the season.
The Browns are the first team to beat Brock Purdy in the regular season. Not only did they beat him, but they also confused and frustrated him all game. If Gardner Minshew is not better in this game, it could be a long day for the Colts and their offense.
Look for the Browns to find just enough offense to win this game and cover the spread. Take the Browns -2 and bet on the under in this game on Sunday. Those are our Browns vs Colts betting picks!
Cleveland Browns vs. Indianapolis Colts Prediction
The final score prediction for this game is the Cleveland Browns 21-17 over the Indianapolis Colts. The Browns get a couple of early touchdowns and then seal the deal late with their third. The defense does the rest. Bet the Browns!
- NFL Pick: Take the Browns -2 and bet on the under
Discover the latest stats and trends of this matchup here.
If you love sports and want more sports betting information follow us as @InsidersBetDig on Twitter and sign up to our mailing list for free betting picks.