The Green Bay Packers travel to San Francisco to face the 49ers, opening both teams’ respective 2022 preseason.
For this 49ers vs. Packers betting predictions article, we’re going to find what insight we can to help you make the best possible NFL picks and start the 2022 season on a winning note.
The Packers and 49ers open their NFL schedules Friday, August 12th. Kick-off is scheduled for shortly after 8:30 PM EDT from Levi’s Stadium in Santa Clara, California. This game can be watched on the NFL Network.
NFL Previous Scoreboards
This is the first game of the preseason on the NFL schedule for the Green Bay Packers and San Francisco 49ers. The last time these two teams met, however, wasn’t all that long ago.
The 49ers secured an NFC Wild Card position, beating the Dallas Cowboys to make it to the divisional round. For their part, the Packers were tied atop the 2021 NFL standings and won the NFC North division.
Divisional Round Playoff
In the divisional round playoff, the crowd at Lambeau Field witnessed the Packers take a 10-3 lead with 11:27 left in the fourth quarter.
With the Packers punting deep in their territory, Talanoa Hufanga scored a 6-yard blocked punt return, paired with a Robbie Gould extra point, tied the game at 10 with 4:41 to go.
San Francisco 49ers got the ball back, and Gould hit a 45-yard field goal as time expired to send the 49ers to the NFC Championship game.
This loss, along with two previous playoff defeats (2013, 2019) to the 49ers, still “haunts” Aaron Rodgers and the Packers to this day.
49rs vs. Packers Betting Prediction
Packers Analysis
Aaron Rodgers will have to wait for another potential playoff matchup to exercise the 49ers’ ghosts from the Packers’ nightmares.
According to Packers Head Coach Matt LaFleur, Rodgers will not play in Green Bay’s first two preseason games.
The earliest Rodgers might hit the field will be in the Packers’ final preseason game against the Kansas City Chiefs.
This leaves quarterbacking duties to Jordan Love, the No. 26 pick in the 2020 NFL Draft. Love and Danny Etling will see the majority of work at quarterback for the Packers.
49ers Analysis
The San Francisco 49ers paid a significant price to get the No. 3 pick in the draft, giving up four draft picks – including three first-round picks – to draft Trey Lance in the 2021 draft. Lance is expected to get a few snaps in before handing the ball over to likely backup Nate Sudfeld.
We state likely because Jimmy Garoppolo is destined to leave the Bay Area after five seasons. Garoppolo is recovering from surgery and working out at team facilities while not attending team meetings or participating in practice.
The 49ers have until August 30th to trade or release Garoppolo before his salary counts against the salary cap.
NFL Injury Report
This is the preseason, so many starters either won’t play or will play limited snaps. However, the Packers have four starters on offense listed as out: wide receiver Christian Watson, tight end Robert Tonyan, left tackle David Bakhtiari, and right tackle Eglton Jenkins.
On defense, the Packers only have to start free safety Darnell Savage is listed as questionable. As for the San Francisco 49ers, only one starter has been listed as questionable: right defensive tackle Erik Armstead.
Starting left defensive tackle Javon Kinlaw may play more snaps than the average starter, with backup Hassan Ridgeway listed as questionable while third-stringer Kalia Davis is listed as out.
San Francisco 49ers vs. Green Bay Packers Betting Preview
This game has meaning for the players who will be fighting for second-string and third-string opportunities on the roster or to potentially impress another team in the league.
We can’t take much from the 2022 NFL stats because there are none or the 2021 NFL statistical rankings because the majority of the players are involved in generating these statistics.
However, considering who will be playing in the game – regardless of how limited that time is – and what positions’ the team’s depth is being tested at, we favor the combination of Lance, Sudfeld, and Brock Purdy to drive the 49ers to victory.
NFL Odds
According to NFL odds, the betting public has come to the same conclusion. The 49ers are the betting favorite listed at -125 on the money line, while the Packers are a +105 underdog at the time of publication.
Notably, the Packers’ odds have been fluctuating between -105 to +105. The point spread is set at 1.5. Again, the 49ers (+1.5) are the favorite, listed at -110 odds. These odds are identical to the Packers (-1.5), who are the underdog but listed at -110.
The total points for Friday’s matchup are set at 32.5, down from 33.5. The over and the under are both listed at -110.
San Francisco 49ers vs. Green Bay Packers Betting Prediction
Our pick is the San Francisco 49ers to cover the spread. With odds and a point spread this close, if the 49ers win, it’ll likely be by more than two, meaning a parlay is the best bet to make for the most value.
But we’re making one pick, and that pick is the 49ers to cover the spread. They have more depth and impact options across the field, leading them to a probable preseason victory. Our pick is the San Francisco 49ers (+1.5) to cover the spread (-110)
NFL Pick: 49ers +1.5 (-110)
49rs vs. Packers Matchup Information
If you love sports and want more sports betting information follow us as @InsidersBetDig on Twitter and sign up to our mailing list for free betting picks.