Just 16 teams are remaining in the 2024 NCAA Tournament, and the Sweet 16 games will take place on Thursday and Friday. There weren’t a ton of upsets in the first weekend, and that’s going to lead to some great battles in the Sweet 16.
Sweet 16 March Madness Picks

- Pick 1: Illinois +2.5.
- Pick 2: Over 173.5.
- Pick: Tennessee ML.
With eight games set to take place this weekend, there is a chance to put together a winning parlay. There will be some great betting options to explore with each game that is on the schedule, and there will be plenty of value.
Here is a look at a March Madness parlay guide that you can use to create some winning bets this weekend.
Sweet 16: Parlay Legs
Illinois Fighting Illini vs. Iowa State Cyclones
When putting together a March Madness parlay guide, it’s always a good idea to find the most value in each wager. There is a great opportunity on Thursday night when the Illinois Fighting Illini battle the Iowa State Cyclones.
This should be one of the top college basketball games today, and it’s Iowa State that is a slim betting favorite at -2.5. While that might be the case, Illinois has been one of the top NCAA basketball teams over the last few weeks of the season.
Fans circled this game on the March Madness bracket upon its release, as it pits two teams that win in different ways against each other. Illinois is the best offensive team in the country, while Iowa State is great on defense.
The old adage says that “Defense wins championships,” but that’s not going to win a game on Thursday night. This Illinois team is absolutely loaded with talent, and they are going to pick up an underdog win.
- Pick: Illinois +2.5.
Alabama Crimson Tide vs. North Carolina Tar Heels
There are some very explosive teams currently playing college basketball, but two of those teams will be taking the court on Thursday night. The Alabama Crimson Tide will be looking to play the role of spoiler against the North Carolina Tar Heels.
When putting together picks and parlays for college basketball, checking out the over/under line is always going to be a good option to explore. That betting line is set at 173.5 total points for this game, and that is an extremely high number.
A March Madness parlay guide is going to ask you to take some risks at times, and that will be the case with this matchup. These two teams were both on top of the college basketball standings for much of the year, and those teams did it by scoring points.
Both teams could have some players on the college basketball injury report ahead of this game, but there will still be plenty of stars. You should also bet the over 173 total points.
- Pick: Over 173.5.
Creighton Bluejays vs. Tennessee Volunteers
When making expert picks for March Madness, you are going to have to show some restraint and patience along the way. That’s why the final bet to include in your perfect parlay is going to be the final game of the Sweet 16 round.
This is arguably one of the most highly-anticipated games on the college basketball schedule today as both teams are loaded with talent. Creighton wants to win games on offense, while Tennessee can get it done in several different ways.
The Tennessee Volunteers have been a popular team when betting on March Madness all season long, and nothing is going to change in this matchup. Tennessee is going to make it hard for the Creighton Bluejays to get good shots, and that will allow them to spread the game out in the second half.
There will be some great bets to make throughout the two nights of the Sweet 16 Round, but these are the three bets that stand out the most.
- Pick: Tennessee ML.
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