In one of the best NFL Matchups of the week – the San Francisco 49ers and Cincinnati Bengals are set to square off in a National Football League tilt on Sunday.
Bengals vs 49ers Picks

- NFL Pick: Cincinnati Bengals at +150 over the San Francisco 49ers
The Cincinnati Bengals record is 3-3 on the season, last place in the AFC North, as we start Week 8 action. The Bengals took their bye week in Week 7 but are coming off back-to-back wins.
For the 49ers, they have dropped two straight games. San Francisco was unable to beat the Browns in Cleveland in Week 6, and then the Vikings got them on Monday Night Football. San Francisco is 5-2 but still in first place in the NFL Standings for the NFC West.
Let’s take a look at the game information and give our Bengals vs 49ers best bets.
Cincinnati Bengals vs. San Francisco 49ers Odds
Bengals vs. 49ers Information
Here is some information on this game played in Week 8 of the NFL Schedule:
Cincinnati Bengals vs San Francisco 49ers
Location of the game: Levi’s Stadium. Santa Clara, CA.
Date & Time: Sunday, October 29. 1:25 pm PST.
How to watch: CBS
Recent Scores
Before we give our Bengals vs 49ers best bets, take a look at the two teams’ scores so far this season.
Cincinnati Bengals 2023 Results
- Sunday, October 1st, 2023: 27-3 loss at Tennessee Titans
- Sunday, October 8th, 2023: 34-20 win at Arizona Cardinals
- Sunday, October 15th, 2023: 17-13 win over Seattle Seahawks
San Francisco 49ers 2023 Results
- Sunday, October 8th, 2023: 42-10 win over Dallas Cowboys
- Sunday, October 15th, 2023: 19-17 loss at Cleveland Browns
- Monday, October 23rd, 2023: 22-17 loss at Minnesota Vikings
Cincinnati Bengals vs. San Francisco 49ers Analysis
Cincinnati wishes their bye was not in Week 7. The Bengals finally started playing good football after struggles to start the season. In losses to the Browns, Ravens, and Titans, the Bengals scored just 10 points per game. In their three wins, they are scoring 23.6 points per game.
It took some time, but Ja’Marr Chase finally got going for the Bengals. One of the best receivers in the league now has 556 yards receiving, which is nearly half the 1,230 yards that quarterback Joe Burrow has thrown for this season.
Looking at the NFL player stats, Joe Mixon is still the guy leading the running game, but he has just one touchdown on the ground this season. Sadly, his NFL MVP odds are still slim.
The Bengals will head home after this game for back-to-back home games. They will take on the Buffalo Bills on Sunday Night Football, and then the Houston Texans to follow.
49ers’ Offense at a Crossroads
The last two weeks have been big-time struggles for the San Francisco 49ers. After steamrolling through the first five weeks, scoring 17 points in their last two games, each did not get the job done. Now, the 49ers may have to go on without Brock Purdy this week. He is in the concussion protocol and on the NFL Injury Report, not likely to play.
If Purdy cannot go in this game, it appears Sam Darnold will get the start for the 49ers. Darnold is a veteran but has thrown one pass attempt all season. This news comes with the news that Christian McCaffrey played banged up last week. He still goes into the end zone and has nearly 600 rushing yards.
Deebo Samuel missed the game as well, which opens up space for Brandon Aiyuk as the team’s top receiver. The 49ers, despite the injuries, rank 2nd in NFL Team Stats for scoring with 28.7 points per game.
San Francisco will take their bye after this week, which may be much needed. Following that, they are at Jacksonville. San Francisco 49ers lines are hard to determine right now with their injuries.
Odds Breakdown
Before we give our Bengals vs 49ers best bets, here are the updated NFL Odds for this game:
- Spread: San Francisco 49ers -3.5, Cincinnati Bengals +3.5
- Total: 43.5
- Moneyline: San Francisco 49ers -175, Cincinnati Bengals +150
Cincinnati Bengals vs. San Francisco 49ers Betting Pick and Prediction
This is hard to do, but we are picking against the San Francisco 49ers at home.
Too many injuries, too many question marks, and a Cincinnati team playing good football. The Bengals win this game straight up on the road.
Our bet for this game is the Cincinnati Bengals at +150 over the San Francisco 49ers on Sunday!
- NFL Pick: Cincinnati Bengals at +150 over the San Francisco 49ers
Discover the latest stats and trends of this matchup here:
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