We are heading into Week 6 of the NFL season, and there are some big games on the schedule this weekend. The Indianapolis Colts visit the Jacksonville Jaguars in a crucial AFC South Division matchup this weekend.
Colts vs JaguarsPicks

NLF Pick: Jacksonville Jaguars -4.5
The home team is a pretty big betting favorite in this matchup, but there are other ways to make bets on this game. Here is a look at some of the top Colts vs Jaguars betting picks to make in this Week 6 showdown.
Indianapolis Colts vs. Jacksonville Jaguars Odds
If you are looking to make Colts vs Jaguars betting picks in Week 6, then you first need to take a close look at the NFL odds that are available. The Jaguars are coming into this game as a 4.5-point betting favorite, and the over/under for this game is also set at 45.5 total points.
You can also make other bets on all NFL matchups, but betting against the spread and looking at the over/under is always the best way to go.
Colts vs. Jaguars Information
Indianapolis Colts vs Jacksonville Jaguars
Location of the game: EverBank Stadium, Jacksonville, FL.
Date & Time: Sunday, October 15. 1:00 PM ET
How to watch: CBS
Indianapolis Colts vs. Jacksonville Jaguars Analysis
Indianapolis Colts Performance Recap and Analysis
The Colts are winning games despite allowing over 401 yards per game this season, and that number is way too high. Indianapolis is averaging 357 yards per game on offense, but they could be without their young QB in this game.
Stopping the run is going to be a big key for the Colts in this game, but they also have to get pressure on a quarterback with solid NFL MVP odds.
Key Injuries
The NFL injury report is going to be interesting to watch this week as Colts quarterback Anthony Richardson is on it. Running back Jonathan Taylor is back, though, and that’s a huge boost for this team.
Betting Trends to Know
- Looking at betting trends is just as important as looking at NFL team stats, and the Colts are 3-2 ATS so far this season.
- The Colts have scored at least 21 points in all five of their games this season.
Jacksonville Jaguars Performance Recap and Analysis
This Jacksonville Jaguars game today will be their first one back in the United States in three weeks, as they just won two straight games in London. Running back Travis Etienne Jr. has solid NFL player stats this season, as he has racked up 396 yards and three touchdowns.
The Jaguars are holding opponents to just 353 yards per game, and they have been elite at stopping the run this season. That is going to be a key for Jacksonville in this matchup, especially early in the game.
Key Injuries
The NFL injury report for the Jaguars lists Zay Jones as questionable, and that could be a big loss if he was not able to suit up.
Betting Trends to Know
- The Jaguars are also 3-2 ATS this season, including two straight games in which they have covered.
Colts vs. Jaguars Betting Picks
- Moneyline (Jaguars -205): Jacksonville is going to win this game at home as it comes at the right time on the NFL schedule for this team.
- Over/Under (Over 45.5): The Jaguars are an explosive offensive team, and the Colts will be trying to keep up. That will push the point total to at least 46 in this game.
- Spread (Jaguars -4.5): The Indianapolis Colts record might be better than expected at this time, but they can’t compete in this game. Bet on the Jaguars to win and cover the spread.
Indianapolis Colts vs. Jacksonville Jaguars Prediction
While you can certainly go a number of different ways when making Colts vs Jaguars betting picks, focusing on the top two options is the way to go. This game will have a big impact on the NFL standings in the AFC South, and Jacksonville can’t afford to take a loss.
Jacksonville is going to win this game at home and cover the spread over the Colts as the top bet to make.
- NFL Pick: Jacksonville Jaguars -4.5
Discover the latest stats and trends of this matchup here.
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