It’s the NFC title game from Levi’s Stadium in Santa Clara, as the Detroit Lions take on the San Francisco 49ers. The Lions and 49ers both come into the game with 12-5 regular season records. The Lions won the NFC North, as the third seed they downed the Los Angeles Rams and Tampa Bay Buccaneers at home.
Lions vs. 49ers Picks

- San Francisco 34-24 over the Lions.
For San Francisco, after grabbing the top seed in the NFC, they took the wildcard weekend off, before eliminating Green Bay last weekend. Let’s get to our Lions vs. 49ers betting picks:
Detroit Lions vs. San Francisco 49ers Odds
Before our Lions vs. 49ers betting picks, the latest NFL Odds:
- Spread: San Francisco 49ers -7, Detroit Lions +7
- Total: 51.5
- Moneyline: San Francisco 49ers -350, Detroit Lions +280
Detroit Lions vs. San Francisco 49ers Information
Information on this game on the NFL Playoff bracket:
Detroit Lions (12-5) @ San Francisco 49ers (12-5)
Where: Levi’s Stadium; Santa Clara, CA
When: Sunday January 28th, 2024; 3:30 pm PST
Watch On: FOX
Detroit Lions vs. San Francisco 49ers Analysis
Dan Campbell, the head coach of the Lions, has led his team to the brink of their first-ever Super Bowl appearance. In the postseason, the Lions have limited their opponents to 23 points in both victories, mirroring their regular-season average of allowing 23.2 points per game. On the offensive front, the Lions boast a formidable arsenal, averaging 27.1 points per game during the regular season and an even more impressive 27.5 points in the postseason.
Amon-Ra St. Brown and Sam LaPorta were solid in the regular season, each scoring 10 touchdowns and amassing over 2,400 receiving yards combined. In the ground game, Jahmyr Gibbs and David Montgomery contributed over 2,000 yards and 23 touchdowns throughout the season.
This balanced performance made Jared Goff’s role as the signal caller a more manageable task. The former Rams quarterback completed 67.3% of his passes for 4,575 yards and 30 touchdowns in the regular season.
Turning to the talented 49ers, the team is fueled by the lingering disappointment of last season’s NFC title game loss. With Christian McCaffrey in their ranks, the 49ers enjoy a significant advantage. McCaffrey, finishing with just under 1,500 rushing yards and 14 ground touchdowns, was key in their recent win over the Packers, scoring two touchdowns.
McCaffrey also featured primarily as a target for quarterback Brock Purdy, alongside Brandon Aiyuk and Deebo Samuel, and the dynamic George Kittle. Kittle’s standout performance last week included four catches for 81 yards and a touchdown. However, Samuel’s early exit from the game raises questions about his availability for the upcoming matchup on Sunday.
On the defensive front, the 49ers have consistently performed at an elite level throughout the season. Dre Greenlaw’s dominant performance last week, featuring eight tackles and two interceptions, played a crucial role in securing the victory. It’s noteworthy that San Francisco did not record a sack in their win over Green Bay.
Detroit Lions vs. San Francisco 49ers Betting Picks
When we go to make our betting picks, several things factor in here. We do believe Deebo Samuel will play for the 49ers. That will be a big lift. The offense is just not the same without him in the game. This is just the second outside game of the season for the Lions. Sure, San Francisco has decent weather, but it makes a difference. Jared Goff simply is not the same quarterback on the road as he is at home. Finally, Christian McCaffrey is on the 49ers, and not the Lions. We like the 49ers to win this game by 10 points. Bet the 49ers -7 over the Lions on Sunday! Those are our Lions vs. 49ers betting picks.
Detroit Lions vs. San Francisco 49ers Prediction
Our final score prediction for this game shows that we are going to take the OVER as well. The 49ers cover the spread, and the over hits. We like the final score to settle in at San Francisco 34-24 over the Lions. Goff throws a couple interceptions, and the 49ers offense hits like crazy. It’s been a fun season for the Lions, but it comes to an end. Take the 49ers at home.
Discover the latest stats and trends of this matchup here:
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