It’s the Buffalo Bills and Los Angeles Chargers in the second game on Saturday in the National Football League. The Buffalo Bills come into the game at 8-6, in a battle with several teams in the AFC for the wildcard spot. Currently, Buffalo is 9th, as they are behind tiebreakers from Cincinnati, Indianapolis and Houston. The Bills have won back-to-back games over the Kansas City Chiefs and Dallas Cowboys.
Bills vs. Chargers Picks

- Pick: Buffalo Bills Spread -13.5.
For the Los Angeles Chargers, their season is all but over. The Chargers are 5-9 on the season and are coming off a loss to the Las Vegas Raiders on Thursday Night Football. The Chargers are last in the AFC West. The Buffalo Bills beat the Los Angeles Chargers 27-17 on November 29th, 2020. Let’s start looking at the Bills vs. Chargers odds for this game:
Buffalo Bills vs. Los Angeles Chargers Odds
Our updated Bills vs. Chargers odds for this game, as we look at all the NFL Odds:
- Spread: Buffalo Bills -13.5, Los Angeles Chargers +13.5
- Total: 42.5
- Moneyline: Buffalo Bills -900, Los Angeles Chargers +600
Buffalo Bills vs. Los Angeles Chargers Information
Before our NFL expert picks, take a look at some information on this game on the NFL schedule for Week 16:
Buffalo Bills vs Los Angeles Chargers
Date & Time: Saturday December 23rd, 2023; 5:00pm PST
Location of the game: SoFi Stadium; Inglewood, CA
How to watch: Peacock
Buffalo Bills vs. Los Angeles Chargers Betting Preview
When looking at the Buffalo Bills’ stats, they check all the boxes. The offense is 6th in the league with 27.1 points per game, and the defense is one of the best in the league, allowing 18.1 points per game. The passing game is in the Top 10 in the league, and rushing has moved to 10th.
But, the Bills are on the outside looking in as we head into NFL Week 16. Josh Allen is 53 yards away from 3,500 on the season, with 26 touchdowns thrown. James Cook has been impressive as of late for the Bills, with 789 yards on the ground this season.
Following this game, Buffalo will host the Patriots on New Year’s Eve, and then play on the road at the Miami Dolphins as they attempt to get into the postseason.
This Los Angeles Chargers roster should be good enough to be in the postseason, but five losses in their last six games have ended any chances, as also ended Brandon Staley as the head coach. The Chargers will go with an interim coach as they close out the season. The final game for Staley saw the Chargers allow 63 points on the road in Vegas.
The Chargers will go with Easton Stick under center. He was not great in his first start. He is taking over for Justin Herbert, who finishes his season with more than 3,100 yards and 20 touchdowns on the season. Keenan Allen is questionable in this game, after sitting out last week. Allen has 1,243 yards and 7 touchdowns. Austin Ekeler will look to finish strong for the Chargers. The running back has carried the football 141 times, for 506 yards and 5 touchdowns on the season.
The Chargers are at the Broncos on New Year’s Eve and then will host the Kansas City Chiefs on January 7th.
Buffalo Bills vs. Los Angeles Chargers Betting Picks
When we make this betting prediction, without Justin Herbert for the Chargers, and with a new coaching staff, we do not expect the Los Angeles Chargers to put up much of a fight. While they will not be as bad as they were against the Raiders, this is going to be a win for Buffalo. The Bills continue getting healthy, and getting back on track in the scores and odds.
The final betting pick for this game is the Buffalo Bills -13.5 over the Los Angeles Chargers. Our final score prediction is the Buffalo Bills 31-10 over the Los Angeles Chargers on Saturday. Hope you liked our look at the Bills vs. Chargers odds for this game!
- Pick: Buffalo Bills Spread -13.5.
Discover the latest stats and trends of this matchup here:
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